Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.

Rapamycin is a macrolide antifungal agent with structural similarity to FK506. It exhibits potent immunosuppressive properties analogous to those of both FK506 and cyclosporin A (CsA). Unlike FK506 and CsA, however, rapamycin does not inhibit the transcription of early T-cell activation genes, inclu...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Koltin, Y, Faucette, L, Bergsma, D J, Levy, M A, Cafferkey, R, Koser, P L, Johnson, R K, Livi, G P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1996117/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.3.1718-1723.1991
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