Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.

Rapamycin is a macrolide antifungal agent with structural similarity to FK506. It exhibits potent immunosuppressive properties analogous to those of both FK506 and cyclosporin A (CsA). Unlike FK506 and CsA, however, rapamycin does not inhibit the transcription of early T-cell activation genes, inclu...

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Detalhes bibliográficos
Main Authors: Koltin, Y, Faucette, L, Bergsma, D J, Levy, M A, Cafferkey, R, Koser, P L, Johnson, R K, Livi, G P
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC369480/
https://ncbi.nlm.nih.gov/pubmed/1996117
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