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Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis
BACKGROUND: Certain mutations in the Deadend1 (Dnd1) gene are the most potent modifiers of testicular germ cell tumor (TGCT) susceptibility in mice and rats. In the 129 family of mice, the Dnd1(Ter) mutation significantly increases occurrence of TGCT-affected males. To test the hypothesis that he Dn...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3693958/ https://ncbi.nlm.nih.gov/pubmed/23773267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-14-54 |
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