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Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability

Environmental agents and genetic variants can induce heritable epigenetic changes that affect phenotypic variation and disease risk in many species. These transgenerational effects challenge conventional understanding about the modes and mechanisms of inheritance, but their molecular basis is poorly...

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Autors principals: Nelson, Vicki R., Heaney, Jason D., Tesar, Paul J., Davidson, Nicholas O., Nadeau, Joseph H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478648/
https://ncbi.nlm.nih.gov/pubmed/22923694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207169109
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