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Measurement of Cancer Cell Growth Heterogeneity through Lentiviral Barcoding Identifies Clonal Dominance as a Characteristic of In Vivo Tumor Engraftment

Advances in the fields of cancer initiating cells and high-throughput in vivo shRNA screens have highlighted a need to observe the growth of tumor cells in cancer models at the clonal level. While in vivo cancer cell growth heterogeneity in xenografts has been described, it has yet to be measured. H...

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Main Authors: Nolan-Stevaux, Olivier, Tedesco, Donato, Ragan, Seamus, Makhanov, Mikhail, Chenchik, Alex, Ruefli-Brasse, Astrid, Quon, Kim, Kassner, Paul D.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693957/
https://ncbi.nlm.nih.gov/pubmed/23840661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067316
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