Endoglin Requirement for BMP9 Signaling in Endothelial Cells Reveals New Mechanism of Action for Selective Anti-Endoglin Antibodies

Endoglin (ENG), a co-receptor for several TGFβ-family cytokines, is expressed in dividing endothelial cells alongside ALK1, the ACVRL1 gene product. ENG and ACVRL1 are both required for angiogenesis and mutations in either gene are associated with Hereditary Hemorrhagic Telangectasia, a rare genetic...

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Autores principales: Nolan-Stevaux, Olivier, Zhong, Wendy, Culp, Stacey, Shaffer, Kathy, Hoover, Joseph, Wickramasinghe, Dineli, Ruefli-Brasse, Astrid
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531442/
https://ncbi.nlm.nih.gov/pubmed/23300529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050920
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