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Characterization of N-terminally mutated cardiac Na(+) channels associated with long QT syndrome 3 and Brugada syndrome
Mutations in SCN5A, the gene encoding the cardiac voltage-gated Na(+) channel hNa(v)1.5, can result in life-threatening arrhythmias including long QT syndrome 3 (LQT3) and Brugada syndrome (BrS). Numerous mutant hNa(v)1.5 channels have been characterized upon heterologous expression and patch-clamp...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Frontiers Media S.A.
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3693076/ https://ncbi.nlm.nih.gov/pubmed/23805106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2013.00153 |
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