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Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines

Genetically engineered mouse models are frequently used to identify pathophysiological consequences of deregulated cell death. Targeting pro-apoptotic or anti-apoptotic proteins of the extrinsic or intrinsic apoptotic signalling cascade is state of the art since more than two decades. Such animal mo...

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Bibliographic Details
Main Authors: Manzl, Claudia, Baumgartner, Florian, Peintner, Lukas, Schuler, Fabian, Villunger, Andreas
Format: Artigo
Language:Inglês
Published: Academic Press 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693039/
https://ncbi.nlm.nih.gov/pubmed/23454286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2013.02.012
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