miRNA Signature of Mouse Helper T Cell Hyper-Proliferation

Helper T cells from a mutant mouse model, LAT Y136F, hyper-proliferate and cause a severe lymphoproliferative disease that kills the mice by six months of age. LAT Y136F mice carry a tyrosine to phenylalanine mutation in the Linker for Activation of T cells (LAT) gene. This mutation leads to a numbe...

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Main Authors: Sommers, Connie L., Rouquette-Jazdanian, Alexandre K., Robles, Ana I., Kortum, Robert L., Merrill, Robert K., Li, Wenmei, Nath, Nandan, Wohlfert, Elizabeth, Sixt, Katherine M., Belkaid, Yasmine, Samelson, Lawrence E.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3692518/
https://ncbi.nlm.nih.gov/pubmed/23825558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066709
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