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A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice
The most common translocation in childhood T-cell acute lymphoblastic leukemia (T-ALL) involves the LMO2 locus, resulting in ectopic expression of the LMO2 gene in human thymocytes. The LMO2 gene was also activated in patients with X-linked Severe Combined Immune Deficiency treated with gene therapy...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3691994/ https://ncbi.nlm.nih.gov/pubmed/21057528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.495 |
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