Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

Acute myeloid leukemia (AML) is a molecularly diverse malignancy with a poor prognosis, whose largest subgroup is characterized by somatic mutations in NPM1, the gene for Nucleophosmin1. These mutations, termed NPM1c, result in cytoplasmic dislocation of Nucleophosmin1 and are associated with distin...

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Detalhes bibliográficos
Main Authors: Vassiliou, George S., Cooper, Jonathan L., Rad, Roland, Li, Juan, Rice, Stephen, Uren, Anthony, Rad, Lena, Ellis, Peter, Andrews, Rob, Banerjee, Ruby, Grove, Carolyn, Wang, Wei, Liu, Pentao, Wright, Penny, Arends, Mark, Bradley, Allan
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084174/
https://ncbi.nlm.nih.gov/pubmed/21441929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.796
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