K(Ca)3.1 Channel-Blockade Attenuates Airway Pathophysiology in a Sheep Model of Chronic Asthma

BACKGROUND: The Ca(2+)-activated K(+) channel K(Ca)3.1 is expressed in several structural and inflammatory airway cell types and is proposed to play an important role in the pathophysiology of asthma. The aim of the current study was to determine whether inhibition of K(Ca)3.1 modifies experimental...

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Main Authors: Van Der Velden, Joanne, Sum, Grace, Barker, Donna, Koumoundouros, Emmanuel, Barcham, Garry, Wulff, Heike, Castle, Neil, Bradding, Peter, Snibson, Kenneth
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691218/
https://ncbi.nlm.nih.gov/pubmed/23826167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066886
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