Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T cell exhaustion in reducing T cell responses

Merkel cell carcinomas (MCC) are rare but highly malignant skin cancers associated with a novel polyomavirus. MCC tumors were infiltrated by T cells, including effector, central memory and regulatory T cells. Infiltrating T cells showed markedly reduced activation as evidenced by reduced expression...

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Detalhes bibliográficos
Main Authors: Dowlatshahi, Mitra, Huang, Victor, Gehad, Ahmed, Jiang, Ying, Calarese, Adam, Teague, Jessica E., Dorosario, Andrew, Cheng, Jingwei, Nghiem, Paul, Schanbacher, Carl, Thakuria, Manisha, Schmults, Chrysalyne, Wang, Linda C., Clark, Rachael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691077/
https://ncbi.nlm.nih.gov/pubmed/23419694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2013.75
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