The DMAP interaction domain of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase is a substrate recognition module

UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase) is an α(2)β(2)γ(2) heterohexamer that mediates the initial step in the formation of the mannose 6-phosphate recognition signal on lysosomal acid hydrolases. We previously reported that the specificity...

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Bibliographic Details
Main Authors: Qian, Yi, Flanagan-Steet, Heather, van Meel, Eline, Steet, Richard, Kornfeld, Stuart A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690890/
https://ncbi.nlm.nih.gov/pubmed/23733939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308453110
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