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Inactivation of Heat Shock Factor Hsf4 Induces Cellular Senescence and Suppresses Tumorigenesis In Vivo

Studies suggest that Hsf4 expression correlates with its role in cell growth and differentiation. However, the role of Hsf4 in tumorigenesis in vivo remains unexplored. In this article, we provide evidence that absence of the Hsf4 gene suppresses evolution of spontaneous tumors arising in p53- or Ar...

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Bibliografski detalji
Glavni autori: Jin, Xiongjie, Eroglu, Binnur, Cho, Wonkyoung, Yamaguchi, Yukihiro, Moskophidis, Demetrius, Mivechi, Nahid F.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690822/
https://ncbi.nlm.nih.gov/pubmed/22355043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0530
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