Heat Shock Factor Hsf1 Cooperates with ErbB2 (Her2/Neu) Protein to Promote Mammary Tumorigenesis and Metastasis

ErbB2/Neu oncogene is overexpressed in 25% of invasive/metastatic breast cancers. We have found that deletion of heat shock factor Hsf1 in mice overexpressing ErbB2/Neu significantly reduces mammary tumorigenesis and metastasis. Hsf1(+/−)ErbB2/Neu(+) tumors exhibit reduced cellular proliferative and...

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Bibliographic Details
Main Authors: Xi, Caixia, Hu, Yanzhong, Buckhaults, Phillip, Moskophidis, Demetrius, Mivechi, Nahid F.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471706/
https://ncbi.nlm.nih.gov/pubmed/22847003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.377481
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