Genetic Knockouts Suggest a Critical Role for HIV Co-Receptors in Models of HIV gp120-Induced Brain Injury

Infection with HIV-1 frequently affects the brain and causes NeuroAIDS prior to the development of overt AIDS. The HIV-1 envelope protein gp120 interacts with host CD4 and chemokine co-receptors to initiate infection of macrophages and lymphocytes. In addition, the virus or fragments of it, such as...

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Main Authors: Maung, Ricky, Medders, Kathryn E., Sejbuk, Natalia E., Desai, Maya K., Russo, Rossella, Kaul, Marcus
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690779/
https://ncbi.nlm.nih.gov/pubmed/22124968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-011-9328-x
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