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Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and recognized by a therapeutic cross-reactive human monoclonal antibody

West Nile virus is an emerging pathogen that can cause fatal neurological disease. A recombinant human monoclonal antibody, mAb11, has been described as a candidate for the prevention and treatment of West Nile disease. Using a yeast surface display epitope mapping assay and neutralization escape mu...

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Detalhes bibliográficos
Main Authors: Sultana, Hameeda, Foellmer, Harald G., Neelakanta, Girish, Oliphant, Theodore, Engle, Michael, Ledizet, Michel, Krishnan, Manoj, Bonafe, Nathalie, Anthony, Karen G., Marasco, Wayne A., Kaplan, Paul, Montgomery, Ruth R., Diamond, Michael S., Koski, Raymond A., Fikrig, Erol
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690769/
https://ncbi.nlm.nih.gov/pubmed/19535627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900093
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