Molecular determinants for cardiovascular TRPC6 channel regulation by Ca(2+)/calmodulin-dependent kinase II

The molecular mechanism underlying Ca(2+)/calmodulin (CaM)-dependent kinase II (CaMKII)-mediated regulation of the mouse transient receptor potential channel TRPC6 was explored by chimera, deletion and site-directed mutagenesis approaches. Induction of currents (I(CCh)) in TRPC6-expressing HEK293 ce...

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Detalhes bibliográficos
Main Authors: Shi, Juan, Geshi, Naomi, Takahashi, Shinichi, Kiyonaka, Shigeki, Ichikawa, Jun, Hu, Yaopeng, Mori, Yasuo, Ito, Yushi, Inoue, Ryuji
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690690/
https://ncbi.nlm.nih.gov/pubmed/23529130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.251249
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