Nitric oxide–cGMP–protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6

We investigated the inhibitory role of the nitric oxide (NO)–cGMP–protein kinase G (PKG) pathway on receptor-activated TRPC6 channels in both a heterologous expression system (HEK293 cells) and A7r5 vascular myocytes. Cationic currents due to TRPC6 expression were strongly suppressed (by ∼70%) by a...

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Detalhes bibliográficos
Main Authors: Takahashi, Shinichi, Lin, Hai, Geshi, Naomi, Mori, Yasuo, Kawarabayashi, Yasuhiro, Takami, Noboru, Mori, Masayuki X, Honda, Akira, Inoue, Ryuji
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652196/
https://ncbi.nlm.nih.gov/pubmed/18617565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.156083
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