Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4

The transcription factor IRF4 regulates immunoglobulin class switch recombination and plasma cell differentiation. Its differing concentrations appear to regulate mutually antagonistic programs of B and plasma cell gene expression. We show IRF4 to be also required for generation of germinal center (...

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Main Authors: Ochiai, Kyoko, Maienschein-Cline, Mark, Simonetti, Giorgia, Chen, Jianjun, Rosenthal, Rebecca, Brink, Robert, Chong, Anita S., Klein, Ulf, Dinner, Aaron R., Singh, Harinder, Sciammas, Roger
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690549/
https://ncbi.nlm.nih.gov/pubmed/23684984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.04.009
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