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TRIF and IRF-3 Binding to the TNF Promoter Results in Macrophage TNF Dysregulation and Steatosis Induced by Chronic Ethanol()

Chronic ethanol (EtOH) abuse results in the development of steatosis, alcoholic hepatitis, and cirrhosis. Augmented TNF-α production by macrophages and Kupffer cells and signaling via the p55 TNF receptor have been shown to be critical for these effects of chronic EtOH; however, the molecular mechan...

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Detalhes bibliográficos
Main Authors: Zhao, Xue-Jun, Dong, Qing, Bindas, Julie, Piganelli, Jon D., Magill, Amy, Reiser, Jakob, Kolls, Jay K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690475/
https://ncbi.nlm.nih.gov/pubmed/18713975
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