Differences in PGE(2) Production between Primary Human Monocytes and Differentiated Macrophages: Role of IL-1β and TRIF/IRF3

Prostaglandin E2 (PGE(2)) is induced in vivo by bacterial products including TLR agonists. To determine whether PGE(2) is induced directly or via IL-1β, human monocytes and macrophages were cultured with LPS or with Pam3CSK4 in presence of caspase-1 inhibitor, ZVAD, or IL-1R antagonist, Kineret. TLR...

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Detalhes bibliográficos
Main Authors: Endo, Yukinori, Blinova, Ksenia, Romantseva, Tatiana, Golding, Hana, Zaitseva, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037220/
https://ncbi.nlm.nih.gov/pubmed/24870145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098517
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