IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels

We and others have shown that regulatory T cells (T(reg)) accumulate dramatically with age in both humans and mice. Such T(reg) accrual contributes to age-related immunosenescence as they reduce the response to tumors and parasite infection. While we reported earlier that aged T(reg) have decreased...

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Autores principales: Raynor, Jana, Sholl, Allyson, Plas, David R., Bouillet, Philippe, Chougnet, Claire A., Hildeman, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690359/
https://ncbi.nlm.nih.gov/pubmed/23805138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00161
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