Mechanism of Endogenous Regulation of the Type I Interferon Response by Suppressor of IκB Kinase ϵ (SIKE), a Novel Substrate of TANK-binding Kinase 1 (TBK1)

TANK-binding kinase 1 (TBK1) serves as a key convergence point in multiple innate immune signaling pathways. In response to receptor-mediated pathogen detection, TBK1 phosphorylation promotes production of pro-inflammatory cytokines and type I interferons. Increasingly, TBK1 dysregulation has been l...

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Detalhes bibliográficos
Main Authors: Marion, James D., Roberts, Charlotte F., Call, R. Jason, Forbes, Jonathan L., Nelson, Kristina T., Bell, J. Ellis, Bell, Jessica K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690000/
https://ncbi.nlm.nih.gov/pubmed/23649622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.440859
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