Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK–TBK1–IKKε–IRF3 complex

TRAF family member-associated NF-κB activator (TANK) is a scaffold protein that assembles into the interferon (IFN) regulator factor 3 (IRF3)-phosphorylating TANK-binding kinase 1 (TBK1)–(IκB) kinase ε (IKKε) complex, where it is involved in regulating phosphorylation of the IRF3 and IFN production....

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Veröffentlicht in:Biochem J
Hauptverfasser: Huang, Li, Xiong, Tao, Yu, Huibin, Zhang, Quan, Zhang, Kunli, Li, Changyao, Hu, Liang, Zhang, Yuanfeng, Zhang, Lijie, Liu, Qinfang, Wang, Shengnan, He, Xijun, Bu, Zhigao, Cai, Xuehui, Cui, Shangjin, Li, Jiangnan, Weng, Changjiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2017
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465970/
https://ncbi.nlm.nih.gov/pubmed/28487378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20161037
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