Gain-of-function Mutations in Transient Receptor Potential C6 (TRPC6) Activate Extracellular Signal-regulated Kinases 1/2 (ERK1/2)

Gain-of-function mutations in the canonical transient receptor potential 6 (TRPC6) gene are a cause of autosomal dominant focal segmental glomerulosclerosis (FSGS). The mechanisms whereby abnormal TRPC6 activity results in proteinuria remain unknown. The ERK1/2 MAPKs are activated in glomeruli and p...

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Main Authors: Chiluiza, David, Krishna, Sneha, Schumacher, Valérie A., Schlöndorff, Johannes
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689983/
https://ncbi.nlm.nih.gov/pubmed/23645677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463059
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