Gain-of-function Mutations in Transient Receptor Potential C6 (TRPC6) Activate Extracellular Signal-regulated Kinases 1/2 (ERK1/2)

Gain-of-function mutations in the canonical transient receptor potential 6 (TRPC6) gene are a cause of autosomal dominant focal segmental glomerulosclerosis (FSGS). The mechanisms whereby abnormal TRPC6 activity results in proteinuria remain unknown. The ERK1/2 MAPKs are activated in glomeruli and p...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Chiluiza, David, Krishna, Sneha, Schumacher, Valérie A., Schlöndorff, Johannes
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689983/
https://ncbi.nlm.nih.gov/pubmed/23645677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463059
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares