Lacritin Rescues Stressed Epithelia via Rapid Forkhead Box O3 (FOXO3)-associated Autophagy That Restores Metabolism

Homeostasis is essential for cell survival. However, homeostatic regulation of surface epithelia is poorly understood. The eye surface, lacking the cornified barrier of skin, provides an excellent model. Tears cover the surface of the eye and are deficient in dry eye, the most common eye disease aff...

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Autori principali: Wang, Ningning, Zimmerman, Keith, Raab, Ronald W., McKown, Robert L., Hutnik, Cindy M. L., Talla, Venu, Tyler, Milton F., Lee, Jae K., Laurie, Gordon W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689958/
https://ncbi.nlm.nih.gov/pubmed/23640897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.436584
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