Proteolytic Processing Regulates Placental Growth Factor Activities

Placental growth factor (PlGF) is a critical mediator of blood vessel formation, yet mechanisms of its action and regulation are incompletely understood. Here we demonstrate that proteolytic processing regulates the biological activity of PlGF. Specifically, we show that plasmin processing of PlGF-2...

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Autori principali: Hoffmann, Daniel C., Willenborg, Sebastian, Koch, Manuel, Zwolanek, Daniela, Müller, Stefan, Becker, Ann-Kathrin A., Metzger, Stephanie, Ehrbar, Martin, Kurschat, Peter, Hellmich, Martin, Hubbell, Jeffrey A., Eming, Sabine A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689943/
https://ncbi.nlm.nih.gov/pubmed/23645683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451831
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