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Activation of Specific Apoptotic Caspases with an Engineered Small Molecule-Activated Protease
Apoptosis is a conserved cellular pathway that results in the activation of cysteine-aspartyl proteases, or caspases. To dissect the non-redundant roles of the executioner caspases-3, -6 and -7 in orchestrating apoptosis, we have developed an orthogonal protease to selectively activate each isoform...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3689538/ https://ncbi.nlm.nih.gov/pubmed/20723762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.07.014 |
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