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Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA
We examined expression of protease-activated receptors 2 (PAR2) and characterized their signaling pathways in rabbit gastric muscle cells. The PAR2 activating peptide SLIGRL (PAR2-AP) stimulated G(q), G(13), G(i1), PI hydrolysis, and Rho kinase activity, and inhibited cAMP formation. Stimulation of...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3688948/ https://ncbi.nlm.nih.gov/pubmed/23825105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066743 |
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