Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA

We examined expression of protease-activated receptors 2 (PAR2) and characterized their signaling pathways in rabbit gastric muscle cells. The PAR2 activating peptide SLIGRL (PAR2-AP) stimulated G(q), G(13), G(i1), PI hydrolysis, and Rho kinase activity, and inhibited cAMP formation. Stimulation of...

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Autores principales: Sriwai, Wimolpak, Mahavadi, Sunila, Al-Shboul, Othman, Grider, John R., Murthy, Karnam S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688948/
https://ncbi.nlm.nih.gov/pubmed/23825105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066743
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