A Point Mutation within Conserved Region VI of Herpes Simplex Virus Type 1 DNA Polymerase Confers Altered Drug Sensitivity and Enhances Replication Fidelity

Herpes simplex virus type 1 (HSV-1) DNA polymerase contains several conserved regions within the polymerase domain. The conserved regions I, II, III, V, and VII have been shown to have functional roles in the interaction with deoxynucleoside triphosphates (dNTPs) and DNA. However, the role of conser...

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Podrobná bibliografie

Vydáno v:	J Virol
Hlavní autoři:	Hwang, Ying T., Zuccola, Harmon J., Lu, Qiaosheng, Hwang, Charles B. C.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2004
Témata:	Replication
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368862/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694096/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.2.650-657.2004
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