A Point Mutation within Conserved Region VI of Herpes Simplex Virus Type 1 DNA Polymerase Confers Altered Drug Sensitivity and Enhances Replication Fidelity

Herpes simplex virus type 1 (HSV-1) DNA polymerase contains several conserved regions within the polymerase domain. The conserved regions I, II, III, V, and VII have been shown to have functional roles in the interaction with deoxynucleoside triphosphates (dNTPs) and DNA. However, the role of conser...

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書誌詳細

出版年:	J Virol
主要な著者:	Hwang, Ying T., Zuccola, Harmon J., Lu, Qiaosheng, Hwang, Charles B. C.
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 2004
主題:	Replication
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368862/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694096/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.2.650-657.2004
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