A Point Mutation within Conserved Region VI of Herpes Simplex Virus Type 1 DNA Polymerase Confers Altered Drug Sensitivity and Enhances Replication Fidelity

Herpes simplex virus type 1 (HSV-1) DNA polymerase contains several conserved regions within the polymerase domain. The conserved regions I, II, III, V, and VII have been shown to have functional roles in the interaction with deoxynucleoside triphosphates (dNTPs) and DNA. However, the role of conser...

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Bibliographische Detailangaben
Hauptverfasser: Hwang, Ying T., Zuccola, Harmon J., Lu, Qiaosheng, Hwang, Charles B. C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC368862/
https://ncbi.nlm.nih.gov/pubmed/14694096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.2.650-657.2004
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