A Point Mutation within Conserved Region VI of Herpes Simplex Virus Type 1 DNA Polymerase Confers Altered Drug Sensitivity and Enhances Replication Fidelity

Herpes simplex virus type 1 (HSV-1) DNA polymerase contains several conserved regions within the polymerase domain. The conserved regions I, II, III, V, and VII have been shown to have functional roles in the interaction with deoxynucleoside triphosphates (dNTPs) and DNA. However, the role of conser...

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Detalhes bibliográficos
Main Authors: Hwang, Ying T., Zuccola, Harmon J., Lu, Qiaosheng, Hwang, Charles B. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC368862/
https://ncbi.nlm.nih.gov/pubmed/14694096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.2.650-657.2004
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