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Imparting Temperature Sensitivity and Attenuation in Ferrets to A/Puerto Rico/8/34 Influenza Virus by Transferring the Genetic Signature for Temperature Sensitivity from Cold-Adapted A/Ann Arbor/6/60

The four temperature-sensitive (ts) loci identified in the PB1 and PB2 gene segments of cold-adapted A/Ann Arbor/6/60 influenza virus, the master donor virus for influenza A virus (MDV-A) FluMist vaccines, were introduced into a divergent A/Puerto Rico/8/34 influenza virus strain. Recombinant A/Puer...

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Bibliografiske detaljer
Main Authors: Jin, Hong, Zhou, Helen, Lu, Bin, Kemble, George
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC368857/
https://ncbi.nlm.nih.gov/pubmed/14694130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.2.995-998.2004
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