Imparting Temperature Sensitivity and Attenuation in Ferrets to A/Puerto Rico/8/34 Influenza Virus by Transferring the Genetic Signature for Temperature Sensitivity from Cold-Adapted A/Ann Arbor/6/60

The four temperature-sensitive (ts) loci identified in the PB1 and PB2 gene segments of cold-adapted A/Ann Arbor/6/60 influenza virus, the master donor virus for influenza A virus (MDV-A) FluMist vaccines, were introduced into a divergent A/Puerto Rico/8/34 influenza virus strain. Recombinant A/Puer...

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Vydáno v:	J Virol
Hlavní autoři:	Jin, Hong, Zhou, Helen, Lu, Bin, Kemble, George
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2004
Témata:	Vaccines and Antiviral Agents
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368857/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694130/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.2.995-998.2004
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