Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Specific Targeting of the Final Step of Virion Maturation

Despite the effectiveness of currently available human immunodeficiency virus type 1 (HIV-1) therapies, a continuing need exists for new drugs to treat HIV-1 infection. We investigated the mechanism by which 3-O-{3′,3′-dimethylsuccinyl}-betulinic acid (DSB) inhibits HIV-1 replication. DSB functions...

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Detalhes bibliográficos
Main Authors: Zhou, Jing, Yuan, Xiong, Dismuke, David, Forshey, Brett M., Lundquist, Christopher, Lee, Kuo-Hsiung, Aiken, Christopher, Chen, Chin Ho
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC368845/
https://ncbi.nlm.nih.gov/pubmed/14694123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.2.922-929.2004
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