Bifunctional Anti-Human Immunodeficiency Virus Type 1 Small Molecules with Two Novel Mechanisms of Action

A class of betulinic acid derivatives was synthesized to target two critical steps in the human immunodeficiency virus type 1 (HIV-1) replication cycle, entry and maturation. Each mechanism of HIV-1 inhibition is distinct from clinically available anti-HIV therapeutics. The viral determinants of the...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Huang, Li, Yuan, Xiong, Aiken, Christopher, Chen, Chin Ho
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2004
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321552/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14742233/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.2.663-665.2004
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