PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells

In normal brain, the side population (SP) phenotype is generated by ABC transporter activity and identifies stem cell and endothelial cell sub-populations by dye exclusion. By drug efflux, the ABCG2 transporter provides chemoresistance in stem cells and contributes to the blood brain barrier (BBB) w...

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Bibliographic Details
Main Authors: Bleau, Anne-Marie, Hambardzumyan, Dolores, Ozawa, Tatsuya, Fomchenko, Elena I., Huse, Jason T., Brennan, Cameron W., Holland, Eric C.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688060/
https://ncbi.nlm.nih.gov/pubmed/19265662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.01.007
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