N-arachidonoyl glycine suppresses Na(+)/Ca(2+) exchanger-mediated Ca(2+) entry into endothelial cells and activates BK(Ca) channels independently of GPCRs

BACKGROUND AND PURPOSE: N-arachidonoyl glycine (NAGly) is a lipoamino acid with vasorelaxant properties. We aimed to explore the mechanisms of NAGly's action on unstimulated and agonist-stimulated endothelial cells. EXPERIMENTAL APPROACH: The effects of NAGly on endothelial electrical signallin...

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Detalhes bibliográficos
Main Authors: Bondarenko, Alexander I, Drachuk, Konstantin, Panasiuk, Olga, Sagach, Vadim, Deak, Andras T, Malli, Roland, Graier, Wolfgang F
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687672/
https://ncbi.nlm.nih.gov/pubmed/23517055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12180
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