GPR55 agonist lysophosphatidylinositol and lysophosphatidylcholine inhibit endothelial cell hyperpolarization via GPR-independent suppression of Na(+)-Ca(2+) exchanger and endoplasmic reticulum Ca(2+) refilling

Lysophosphatidylinositol (LPI) and lysophosphatidylcholine (LPC) are lipid signaling molecules that induce endothelium-dependent vasodilation. In addition, LPC suppresses acetylcholine (Ach)-induced responses. We aimed to determine the influence of LPC and LPI on hyperpolarizing responses in vitro a...

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Publicado en:Vascul Pharmacol
Autores principales: Bondarenko, Alexander I., Montecucco, Fabrizio, Panasiuk, Olga, Sagach, Vadim, Sidoryak, Nataliya, Brandt, Karim J., Mach, François
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520228/
https://ncbi.nlm.nih.gov/pubmed/28064014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vph.2017.01.002
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