GPR55 agonist lysophosphatidylinositol and lysophosphatidylcholine inhibit endothelial cell hyperpolarization via GPR-independent suppression of Na(+)-Ca(2+) exchanger and endoplasmic reticulum Ca(2+) refilling

Lysophosphatidylinositol (LPI) and lysophosphatidylcholine (LPC) are lipid signaling molecules that induce endothelium-dependent vasodilation. In addition, LPC suppresses acetylcholine (Ach)-induced responses. We aimed to determine the influence of LPC and LPI on hyperpolarizing responses in vitro a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Vascul Pharmacol
Prif Awduron: Bondarenko, Alexander I., Montecucco, Fabrizio, Panasiuk, Olga, Sagach, Vadim, Sidoryak, Nataliya, Brandt, Karim J., Mach, François
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520228/
https://ncbi.nlm.nih.gov/pubmed/28064014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vph.2017.01.002
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