A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects

BACKGROUND AND PURPOSE: The development of potent and selective inhibitors of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) via DAG lipases (DAGL) α and β is just starting to be considered as a novel and promising source of pharmaceuticals for the treatment of disorders that...

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Detalhes bibliográficos
Main Authors: Bisogno, Tiziana, Mahadevan, Anu, Coccurello, Roberto, Chang, Jae Won, Allarà, Marco, Chen, Yugang, Giacovazzo, Giacomo, Lichtman, Aron, Cravatt, Benjamin, Moles, Anna, Di Marzo, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Themed Section: Cannabinoids 2012, Part Two
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687659/
https://ncbi.nlm.nih.gov/pubmed/23072382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12013
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