Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex

Cannabinoid (CB) agonists suppress nausea in humans and animal models; yet, their underlying neural substrates remain largely unknown. Evidence suggests that the visceral insular cortex (VIC) plays a critical role in nausea. Given the expression of CB(1) receptors and the presence of endocannabinoid...

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Publicado no:Neuropharmacology
Main Authors: Sticht, Martin A., Limebeer, Cheryl L., Rafla, Benjamin R., Abdullah, Rehab A., Poklis, Justin L., Ho, Winnie, Niphakis, Micah J., Cravatt, Benjamin F., Sharkey, Keith A., Lichtman, Aron H., Parker, Linda A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698202/
https://ncbi.nlm.nih.gov/pubmed/26541329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.10.039
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