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Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility

IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity. However, how mutations in IDPs elicit diseases, remain elusive. Herein, we have identified tumor suppressor PTEN as an intrinsically disordered protein (IDP) and elucidated the molecular principles by...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Malaney, Prerna, Pathak, Ravi Ramesh, Xue, Bin, Uversky, Vladimir N., Davé, Vrushank
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687229/
https://ncbi.nlm.nih.gov/pubmed/23783762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02035
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