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Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility
IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity. However, how mutations in IDPs elicit diseases, remain elusive. Herein, we have identified tumor suppressor PTEN as an intrinsically disordered protein (IDP) and elucidated the molecular principles by...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687229/ https://ncbi.nlm.nih.gov/pubmed/23783762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02035 |
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