Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility

IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity. However, how mutations in IDPs elicit diseases, remain elusive. Herein, we have identified tumor suppressor PTEN as an intrinsically disordered protein (IDP) and elucidated the molecular principles by...

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Detaylı Bibliyografya
Asıl Yazarlar: Malaney, Prerna, Pathak, Ravi Ramesh, Xue, Bin, Uversky, Vladimir N., Davé, Vrushank
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687229/
https://ncbi.nlm.nih.gov/pubmed/23783762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02035
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