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Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility

IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity. However, how mutations in IDPs elicit diseases, remain elusive. Herein, we have identified tumor suppressor PTEN as an intrinsically disordered protein (IDP) and elucidated the molecular principles by...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Malaney, Prerna, Pathak, Ravi Ramesh, Xue, Bin, Uversky, Vladimir N., Davé, Vrushank
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group 2013
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687229/
https://ncbi.nlm.nih.gov/pubmed/23783762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02035
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