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DNA cytosine methylation: Structural and thermodynamic characterization of the epigenetic marking mechanism
DNA cytosine methyltransferases regulate the expression of the genome through the precise epigenetic marking of certain cytosines with a methyl group, and aberrant methylation is a hallmark of human diseases including cancer. Targeting these enzymes for drug design is currently a high priority. We h...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687104/ https://ncbi.nlm.nih.gov/pubmed/23528166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400163k |
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