Endoplasmic Reticulum Stress Induces Fibrogenic Activity in Hepatic Stellate Cells through Autophagy

BACKGROUND & AIMS: Metabolic stress during liver injury enhances autophagy and provokes stellate cell activation, with secretion of scar matrix. Conditions that augment protein synthesis increase demands on the endoplasmic reticulum (ER) folding capacity and trigger the unfolded protein response...

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Autori principali: Hernández-Gea, Virginia, Hilscher, Moira, Rozenfeld, Raphael, Lim, Maribel P, Nieto, Natalia, Werner, Sabine, Devi, Lakshmi A., Friedman, Scott L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686909/
https://ncbi.nlm.nih.gov/pubmed/23485523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2013.02.016
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